Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant
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چکیده
منابع مشابه
Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant.
A murine gammaherpesvirus-68 (MHV-68) mutant with deregulated transcription of its ORF50 transactivator was severely impaired in latency establishment. The deregulated virus showed reduced immunogenicity, probably reflecting a lower antigen load. However, it still elicited effective immunity to a subsequent wild-type (WT) virus challenge. Infection was not completely prevented, but was very sub...
متن کاملForced lytic replication impairs host colonization by a latency-deficient mutant of murine gammaherpesvirus-68.
A regulated switch between latent and lytic gene expression is common to all known herpesviruses. However, the effects on host colonization of altering this switch are largely unknown. We deregulated the transcription of the gene encoding the major lytic transactivator of murine gammaherpesvirus-68, ORF50, by inserting a new and powerful promoter element in its 5' untranslated region. In vitro,...
متن کاملB cells regulate murine gammaherpesvirus 68 latency.
The dynamics of the establishment of, and reactivation from, gammaherpesviruses latency has not been quantitatively analyzed in the natural host. Gammaherpesvirus 68 (gammaHV68) is a murine gammaherpesvirus genetically related to primate gammaherpesviruses that establishes a latent infection in infected mice. We used limiting dilution reactivation (frequency of cells reactivating gammaHV68 in v...
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Toll-like receptors (TLRs) are known predominantly for their role in activating the innate immune response. Recently, TLR signaling via MyD88 has been reported to play an important function in development of a B-cell response. Since B cells are a major latency reservoir for murine gammaherpesvirus 68 (MHV68), we investigated the role of TLR signaling in the establishment and maintenance of MHV6...
متن کاملAbsence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice.
Murine gammaherpesvirus 68 (MHV-68) is a natural pathogen of mice which causes an acute lung infection and establishes a latent infection in B lymphocytes. In this paper we describe the infection in transgenic B cell-deficient (muMT) mice, to determine whether a latent infection can be established in a mouse lacking circulating B lymphocytes. Little difference was observed in the acute lung inf...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2004
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.19592-0